Karyotype Activity: Build a Baby from Egg and Sperm

⭐ Get this karyotype activity at a discount in my complete Reproduction Unit! ⭐

This karyotyping activity clearly shows that gametes have 23 chromosomes which combine to make a baby karyotype with 46. Nicely illustrates sexual reproduction for middle school students without getting too awkward!

This activity reinforces:

  • Sexual reproduction requires two parents.
  • Gametes have half the number of chromosomes as the parents.
  • Gametes combine to make a zygote in the process of fertilization.
  • Chromosomes have homologous pairing and differ based on size and banding pattern.
  • A karyotype is an organized map of chromosomes.
  • Different organisms have different numbers of chromosomes.
  • XX makes a female offspring and XY makes a male offspring.

In this activity, students will:

  • Read background information about sexual reproduction, including the terms gameteszygotefertilizationspermegg, and homologous chromosomes.
  • Obtain an egg and a sperm graphic. (We do this activity in pairs, so one student gets the male gamete and the other gets a female gamete.)
  • Cut out the chromosomes and match the homologous pairs using a provided key.
  • Paste the homologous chromosome pairs onto their karyotype page and identify whether it is male or female.
  • Answer follow-up questions on a worksheet.

Includes:

  • Introductory reading passage with human chromosome key
  • Egg and sperm graphics (2 versions to make male and female babies)
  • Blank karyotype
  • Follow-up questions worksheet
  • Helpful teacher notes

NGSS Standards:

  • MS-LS3-2
  • Science & Engineering Practice: Developing and using models

Teacher Notes:

  • Get this activity at a discount in my complete Reproduction Unit!
  • Please note: This karyotype activity is NOT editable.
  • Answer key included.
  • You can also shop my TPT store!

Related Standards:

  • NGSS MS-LS3-2: Develop and use a model to describe why asexual reproduction results in offspring with identical genetic information and sexual reproduction results in offspring with genetic variation.

$3.99

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Grade Levels: 6, 7, 8, 9, 10, 11, 12 NGSS Standard: MS-LS3-2